State of the art in human adipose stem cells and their role in therapy Alina Simona Sovrea, Adina Bianca Bosca, Anne-Marie Constantin, Eleonora Dronca, Aranka Ilea Nowadays, adipose tissue appears to be the most valuable source in regenerative cell therapy, due to the following characteristics: high accessibility, high expression in a large number of individuals, high self-renewal and ability to differentiate, and hematopoietic support to the implant area.
Its therapeutic potential has been experimentally observed in a broad spectrum of diseases with high population impact: diabetes, myocardial infarction, Parkinson disease, bone fractures, facial reconstruction or loss of subcutaneous tissue due to congenital abnormalities e. Over clinical trials using adipose-derived stem cells ASCsmajority phase I or phase II, have been registered with the National Institutes of Health NIHand in the short term no adverse reactions or significant risks were identified.
Parallel with regulatory frameworks that control their safety and assess their efficacy, phase III trials are being developed. Although transplantation with adipose tissue is becoming more and more popular, there are still important drawbacks and technical challenges to be addressed, and clinical strategies to be developed.
This review explores in a concise manner the present body of knowledge concerning ASCs and their implication in therapy.
Often, they are associated with persistent left superior vena cava PLSVC draining into the left atrium, and in this situation, there is a double intracardiac shunt, right-to-left and left-to-right.
They are asymptomatic in the majority of the cases.
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Each ordinary imagistic method transthoracic echocardiography, contrast transesophageal echocardiography, angiography can be helpful in finding the diagnosis, but enhanced computed tomography scan can give an irrefutable diagnosis. The surgical intervention may consist in the recreation of a roof for the coronary sinus, and anastomosis of the PLSVC to the right atrial appendage. This type of non-Hodgkin s lymphoma NHL can develop in the lymph nodes in most cases, or in extranodal sites the most frequent involvement being the digestive tract, but also the thyroid, central nervous system, testes, etc.
The addition of monoclonal antibodies to standard chemotherapy in the therapeutic approach of DLBCL leads to some net superior results to those obtained by chemotherapy alone. Based on these findings, an explanation for the differences in clinical outcome and therapy response was attempted. The important progresses made in the understanding of DLBCL heterogeneity were based on molecular biology studies and showed differences in chromosomal alterations and in signaling pathways activation.
These findings aim global fat burner review paved the way for new therapeutic targets in order to improve therapy response.
Symptoms in ASD may be absent, but palpitations and dyspnea in children sometimes reveal a complex structural and CHD. Diagnosis is established usually by transthoracic echocardiography, but in more complex cases such as coronary sinus defect, enhanced computed tomography or cardiac magnetic resonance may be used. Indication for closure depends on the dimension and raynaud este cauzată de pierderea în greutate the hemodynamical impact.
There are two methods for closure: surgical and interventional. The most important issue in the interventional closure is the anatomical aspect related to the position of the defect.
Both methods may have complications. Complex cases in children usually are not recommended for interventional closure, surgery being the recommended method.
Oversizing of the device to be implanted according to the sizing balloon and not to the initial defect diameter may give a solution for large ASDs. Interventional closure of large defects in small children with an aneurysmal, multi-fenestrated, malaligned septum, or with other CHD associated may be challenging. Complications are present for both types of closure, but they are relatively different.
In order to explain this behavior, many investigations have been conducted in recent years, most of them focusing on identification of potential prognostic and therapeutic markers involved in the pathogenesis of tongue cancers.
The cases were selected from the archives of the Laboratory of Pathology, Emergency County Hospital, Craiova, Romania, from the period. Reactivity for the investigated markers was recorded in both primary tumors, parenchymal and stromal, and in lymph node metastases, and also in normal or dysplastic mucosa adjacent to tumor lesions.
In addition, all of these markers were expressed stronger in the invasion front and especially in the lymph node metastatic forms. This immunoprofile would suggest their implication in loco-regional invasion and dissemination processes, allowing the selection of the most aggressive forms of tongue squamous carcinoma.
Materials and Methods: The study divided 26 Wistar rats into two experimental groups in which sepsis was induced through the intraperitoneal injection of different Escherichia coli cultures [Group 1: Extended-spectrum beta-lactamase ESBL -producing culture and Group 2: Standardized ATCC culture] and a control group. IL-6 levels were determined at 5 and 24 hours post-inoculation and immunohistochemistry IHC was performed on tissue samples from the sacrificed animals.
Results: Mean plasma IL-6 levels in Group 1 peaked at 5 hours [ IL-6 levels in Group 1 were elevated compared to Group 2, at 5 hours The results did not show an increase over control levels at either 5 hours No statistically significant correlations were found between the tissue level quantification of IL-6 and serum values at 24 hours in either group.
Accumulation of IL-6 in lung, kidney and spleen tissue can be observed from the beginning of inflammation. The clinical and histological classification of periocular basal cell carcinoma pBCC is essential in order to establish the risk of recurrence and to compare the results of the treatment. Until now, there is no unitary histological classification of pBCC. Aim: The aim of this study is to identify the demographic, clinical and histopathological characteristics of adult patients with pBCC, in order to obtain useful data for comparison in other investigations and to identify the histological origin of this eyelid tumor, as aim global fat burner review are only hypothesis on this issue.
Materials and Methods: A descriptive retrospective study was conducted on a series of 39 consecutive patients over the age of 20, who were surgically treated for pBCC in the 2nd Ophthalmology Clinic of the Prof.
Results: A total of 39 histopathologically diagnosed cases of pBCC were evaluated.
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The mean age at resection was of 66 years range: years. As for gender, 17 The pBCC occurred on the right side in 18 Of all removed specimens, 24 The most common histological subtype was nodular, accounting for 26 Adenoid BCC was identified in four Squamous differentiation basosquamous subtype was identified in eight Conclusions: Our retrospective study indicates that most of pBCCs developed particularly in elderly female patients and tumors were located in the lower eyelid with a left side and lower eyelid preferences.
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Most of our pBCC cases were histologically classified as nodular subtype, and morpheaform and basosquamous form affected mostly the lower eyelid. We can conclude that our results showed a demographic, clinical, histological, and IHC profile which seems to be representative for Central and Eastern European countries, maybe due to the same genetic predisposition and environmental factors.
Complications related to breast reconstruction after mastectomy using multiple surgical techniques - a national and international comparative analysis Silviu-Adrian Marinescu, Catalin-Gheorghe Bejinariu, Elena Sapte, Marius Cristian Marinas, Carmen Giuglea The present paper describes and analyzes complications related to alloplastic breast reconstruction, as well as those associated with surgical techniques involving myocutaneous flaps.
The article also contains a comparative analysis of the results obtained with the data in the international specialized literature. The statistical analysis is primary based on data obtained from patients included in the National Breast Reconstruction Program developed within the Bagdasar-Arseni Emergency Clinical Hospital, Bucharest, Romania, between and In order to highlight and present a thorough comparison between the possible long-term complications associated with multiple reconstructive techniques, the paper also includes data related to patients who have undergone such surgical interventions in the aforementioned Health Unit, but which were not included in the national program, resulting a total of 73 reconstructive surgical interventions.
The research results show that the overall rate of complications was In the authors opinion, risks of complications are moderated in relation with breast reconstruction surgery. However, the complication rate significantly varies depending on the chosen technique.
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The lowest risk levels registered in this study were associated with the breast reconstruction using the two-stage expander-implant technique. The analysis compares the achieved results with data provided by international studies, the main differences being caused by the status of the medical infrastructure, as well as the moment of hospital admission that is primarily determined by the level of medical education.
Multiple versus unifocal breast cancer: clinicopathological and immunohistochemical differences Andrian Panuta, Iulian Radu, Bogdan Gafton, Nicolae Ioanid, Cristina Terinte, Dan Ferariu, Mihaela Buna-Arvinte, Dragos Viorel Scripcariu, Viorel Scripcariu Multiple breast cancer MBC is a controversial topic due to the lack of a consensus regarding its definition, classification issues and imprecise management recommendations in current reference guidelines.
In four years, patients with breast cancer BC were surgically treated in our Unit, 91 We present the results of our retrospective case-control study that performed a comparison between the clinicopathological characteristics and immunohistochemical IHC profiles of our MBC group versus a control group, represented by a sample of cases randomly chosen from those with unifocal breast cancer UBC.
This study aims at expanding the range effectiveness of PRF in promoting bone healing by histological evaluation. Materials and Methods: We performed a pair of two calvaria defects on 35 Wistar rats. The left defect was left empty aim global fat burner review a control and the right defect was augmented with PRF. After 45 days, the experiment was terminated and the calvaria were collected and underwent morphological and histological analysis. Results: New bone formations have been shown to be prevalent in the PRF augmented defect.
Conclusions: PRF increases the body aim global fat burner review natural ability to heal and regenerate bone. The study included 40 cases of heart fragments that were processed by the usual paraffin inclusion technique, followed by a semi-quantitative evaluation of histopathological parameters, which summed, allowed the establishment of a HCS. In case of MMP-9, the immunostaining intensity analysis in relation to the HCS level revealed insignificant differences, but we found an association of increased and moderate intensity with low HCS.
Co-morbidities in the multiple victims of the silent killer in carbon monoxide poisoning Camelia-Oana Muresan, Roxana Eugenia Zavoi, Raluca Oana Dumache, Cris Virgiliu Precup, Veronica Ciocan, Ovidiu Stefan Bulzan, Charoula Florou, Alexandra Enache Carbon monoxide CO remains an insidious and silent killer due to its physical and chemical properties; its lethal effects are encountered in cases of household accidents, occupational hazards or suicide.
Deaths due to CO poisoning were studied retrospectively in the period at the Institute of Forensic Medicine, Timisoara, Romania. These cases represent 1. There have been cases of single deaths and cases with multiple victims - concomitant deaths.
The analysis of lethal CO intoxication cases that occurred in aim global fat burner review circumstances incomplete burning with CO accumulation, fires - associated with burns, death in the fountain - due to fossil fuel pump failure, suicide due to exhaust gases was based on the examination of autopsy files.
In this type of poisoning, the forensic examination of the body is marked by the non-specific character of most of the macroscopic and microscopic changes. Although inconstant, these types of changes e. In all cases, the cerebral and cardio-pulmonary modification and their contribution to the cause of death were studied. Microscopic aspects of junction between dental hard tissues and composite material depending on composite insertion: layering versus bulk-fill Ruxandra-Ilinca Matei, Liana Todor, Emilia Albinita Cuc, Mihai Raul Popescu, Lucian Paul Dragomir, Anne-Marie Rauten, Anca Porumb Polymerization stresses ez burner fat adhesive structure could determine an adhesive or cohesive failure and interfacial gaps forming.
Some clinical procedures - as light curing composite resin layering in mm increments especially for dental fills or using dental reconfiguring clear acetate crowns - are sat up to combat in some way the polymerization shrinkage. This study approaches the manner how clinical dental adhesive application could influence the hard dental tissues-composite materials interface. The sample studied consisted of 12 upper bicuspids, extracted for orthodontic reasons.
In our study, we chose the adhesion technique in two steps.
We prepared enamel and dentine areas, and then filled them with light-polymerization composite. After that, the teeth were subject of microscopic investigations, at x and x magnification. As conclusion of our study, we sustain that light curing composite resin applying clinical technique by layering or with acetate crown might influence a good dental restoration clinical performance.
Clinical relevance and accuracy of p63 and TTF-1 for better approach of small cell lung carcinoma versus poorly differentiated aim global fat burner review squamous cell carcinoma Daniela Gurgus, Mirela Loredana Grigoras, Andrei Gheorghe Marius Motoc, Carmen Lacramioara Zamfir, Marioara Cornianu, Cosmin Ioan Faur, Daniel Laurentiu Pop, Roxana Folescu Lung cancer high mortality rate remains a major problem, despite the actual progress in its early detection and therapeutic design.
Since lung cancer treatment requires separation of tumors in small cell carcinoma and non-small cell carcinoma, the histopathological diagnosis focuses on this basic distinction, while immunohistochemistry contributes considerably to confirm the diagnosis accuracy. In order to check the assumption that p63 is a useful marker for squamous cellular differentiation, we used two antibodies: anti-p63 and anti-thyroid transcription factor-1 TTF-1based on their immunoexpression to differentiate small cell lung carcinoma SCLC from poorly differentiated nonkeratinizing squamous cell carcinoma SCC.
Our study included 48 cases of lung carcinoma lung biopsies and wedge resection formalin-fixed and paraffin-embedded.
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Our results are useful for a targeted therapy, as long as they point out a significant role in marking of the correct diagnosis of lung tumors.
The potential curative and preventive effects of garlic on testosterone-induced benign prostatic hyperplasia in orchiectomized rats Wael Amin Nasr El-Din, Islam Omar Abdel Fattah Benign prostatic hyperplasia BPH is a common aging disease in men. Garlic is known to have anti-proliferative effects. Therefore, this study was designed to investigate the curative and preventive effects of garlic on BPH in rats. Rats were divided into aim global fat burner review groups: control group, orchiectomized group where rats were subjected to bilateral orchiectomies operationBPH group [BPH was induced by intramuscular injection of testosterone TE enanthate once weekly for five weeks after orchiectomy], curative group where rats were injected with TE for five weeks followed by daily administration of garlic powder for other five weeksand preventive group where rats were given garlic powder simultaneously with TE injections for five weeks.
Serum levels of Pierdere în greutate hamilton scoția and prostate-specific antigen PSA were measured, and prostate weighed and processed for light microscopic, immunohistochemical and transmission electron microscopy TEM examination. Histologically and morphometrically, BPH group showed epithelial hyperplasia, stromal expansion and reduced acinar lumens that were significantly improved in both curative and preventive groups.
These results were reversed in both curative and preventive groups.
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TEM showed nuclear irregularities, dilated endoplasmic reticulum ER cisterns, and lost cell boundaries, secretory vesicles and apical microvilli. Most of the previous changes were minimized in preventive group more than in curative one.
Patients, Materials and Methods: We included patients with SBTs, evaluated by SBCE and furthermore explored, for which a final histopathological diagnosis was made, either on biopsy tissue samples, or on surgical specimens, using routine techniques and immunohistochemistry. The SBCE findings and reports were reviewed in order to assess the main macroscopic features of the SBTs, which were further correlated with the histological type.
All SBTs presented as protruding lesions. Features as size, color, type, shape, discoloration, presence of mucosa ulceration, bleeding stigmata or potential, contributed outlining a prototype. SBCE was accurate in terms of localization and suspected diagnosis. Conclusions: Even if SBCE is a purely visual technique, thorough examination and rigorous analysis of macroscopic features, as aim global fat burner review as adoption of a structured terminology, may successfully predict the final diagnosis, empowering SBCE not only as a trust comrade in the diagnostic pathways of SBTs, but also as a valuable standalone technique mandating the final therapeutic decision.
Complex evaluation in patients with knee osteoarthritis Magdalena Rodica Traistaru, Diana Kamal, Daniela Teodora Maria, Marian Valentin Zorila, Dragos Ovidiu Alexandru, Otilia Constantina Rogoveanu, Mirela Radu, Kamal Constantin Kamal Knee osteoarthritis KOA is a very common, slowly progressive and incurable articular disease resulting in the breakdown of cartilage and bone in the joint, which causes significant discomfort, pain and disability, with a significant socio-economic impact.
The aim of our observational study for patients with symptomatic Aim global fat burner review was to investigate the changes of C-terminal telopeptide of type II collagen CTX-II in serum pre and post a complex rehabilitation program and to establish the correlation between all studied parameters [clinical, functional, serum CTX-II sCTX-II and histological aspects obtained through arthroscopy].
Duringwe performed an observational study including 24 patients, between 59 and 76 years old, diagnosed with KOA. Studied patients were completely assessed before T1 and four months after a complex rehabilitation program T2. In the histological assessment of our patients, we observed that the cells of the superficial areas were round and hypertrophic, the cartilage tissue had few proteoaminoglycans and glycosaminoglycans, with an airy aspect of the matrix and degenerate cells, aim global fat burner review reduced.
After positive diagnosis, the complete treatment, including the rehabilitation program, seems to be the ideal option for improving the CTX-II values, as well as the quality of life in KOA patients. A series of discrepancies may occur, one of these being a disturbance between dental age and bone age. The assessment of bone age is best made with the cervical vertebral maturation CVM method, simplified by Baccetti et al.
The sample studied consisted of orthodontic patients.